Scientific Projects and Clinical Researches

1. T-Regulatory, CD4+, CD8+ Cells and CD4/CD8 Ratio in Cancer Patients: Associated with Immunotherapy Response

Objective: To assess how changes in immune cell counts may influence the effectiveness of treatment.
Funding: Supported by a research grant from the RA Ministry of Education, Science, Culture, and Sports.
Principal Investigator: Samvel Bardakhchyan

Team Members:

Astghik Voskanyan

Lusine Harutyunyan

Lilit Matinyan

Amalya Sargsyan

2. National Registries for Benign and Malignant Hematological Diseases

The program includes the establishment of the following specialized registries: Chronic Lymphocytic Leukemia Registry

  Principal Investigator: Gevorg Saghumyan

• Acute Leukemia Registry
  Principal Investigator: Nare Martirosyan
• Philadelphia-Negative Myeloproliferative Neoplasms Registry
  Principal Investigator: Astghik Voskanyan
• Myelodysplastic Syndrome Registry (in collaboration with France)
  Principal Investigator: Anna Sevoyan
• Non-Hodgkin Lymphoma Registry
  Principal Investigator: Lusine Sahakyan
• National Thalassemia Registry of Armenia
  Principal Investigator: Lusine Sahakyan
• INHERENT: International Hemoglobinopathy Research Network
  Principal Investigator: Maria Badikyan

3. Clinical Studies

• Gut Microbiota Composition in Patients Undergoing Long-Term Antibiotic Therapy
  Assessing the link between C. difficile infection and the presence of beneficial lactic acid bacteria.
  Principal Investigator: Diana Soghomonyan
• Oral Azacitidine as Maintenance Therapy
  For intermediate- to high-risk AML patients in remission not eligible for bone marrow transplantation.
  Principal Investigator: Anna Sevoyan
• Comparison of Oral Anticoagulants vs. Low Molecular Weight Heparin/Aspirin
  As thrombosis prevention in newly diagnosed myeloma patients undergoing induction therapy.
  Principal Investigator: Nerses Ghahramanyan
• Atenativ: Safety, Efficacy, and Pharmacokinetics Study
  In patients with congenital antithrombin deficiency undergoing childbirth or surgery.
  Principal Investigator: Heghine Khachatryan
• ANB-002: Safety and Pharmacodynamics Study
  Single-dose evaluation in patients with Hemophilia B.
  Principal Investigator: Heghine Khachatryan
• TiUMBio TU7710 Phase Ib Clinical Trial
  Safety, pharmacokinetics, and pharmacodynamics study in patients with Hemophilia A or B.
  Principal Investigator: Heghine Khachatryan
• Role of Helicobacter pylori in Non-Hodgkin Lymphoma
  Exploring the bacterium’s role in the pathogenesis, diagnosis, treatment efficacy, and disease progression.
  Principal Investigator: Lusine Sahakyan
• ERNEST 3 – Observational Study of Myelofibrosis
  A modern clinical-epidemiological study under the European Leukemia Network (ELN).
  Principal Investigator: Maria Badikyan

Scientific Events and Conferences

In addition to conducting research, the Center organizes scientific conferences supported through various research grants, contributing to knowledge exchange and professional development.