Ongoing Research Projects

1. T-Regulatory, CD4+, CD8+ Cells and CD4/CD8 Ratio in Cancer Patients: Associated with Immunotherapy Response

Objective: To assess how changes in immune cell counts may influence the effectiveness of treatment.
Funding: Supported by a research grant from the RA Ministry of Education, Science, Culture, and Sports.
Principal Investigator: Samvel Bardakhchyan
Team Members: Astghik Voskanyan, Lusine Harutyunyan, Lilit Matinyan, Amalya Sargsyan

2. National Registries for Benign and Malignant Hematological Diseases

The program includes the establishment of the following specialized registries: Chronic

·         Lymphocytic Leukemia Registry
  Principal Investigator: Gevorg Saghumyan

• Acute Leukemia Registry
  Principal Investigator: Nare Martirosyan
• Philadelphia-Negative Myeloproliferative Neoplasms Registry
  Principal Investigator: Astghik Voskanyan
• Myelodysplastic Syndrome Registry (in collaboration with France)
  Principal Investigator: Anna Sevoyan
• Non-Hodgkin Lymphoma Registry
  Principal Investigator: Lusine Sahakyan
• National Thalassemia Registry of Armenia
  Principal Investigator: Lusine Sahakyan
• INHERENT: International Hemoglobinopathy Research Network
  Principal Investigator: Maria Badikyan

3. Clinical Studies

• Gut Microbiota Composition in Patients Undergoing Long-Term Antibiotic Therapy
  Assessing the link between C. difficile infection and the presence of beneficial lactic acid bacteria.
  Principal Investigator: Diana Soghomonyan
• Oral Azacitidine as Maintenance Therapy
  For intermediate- to high-risk AML patients in remission not eligible for bone marrow transplantation.
  Principal Investigator: Anna Sevoyan
• Comparison of Oral Anticoagulants vs. Low Molecular Weight Heparin/Aspirin
  As thrombosis prevention in newly diagnosed myeloma patients undergoing induction therapy.
  Principal Investigator: Nerses Ghahramanyan
• Atenativ: Safety, Efficacy, and Pharmacokinetics Study
  In patients with congenital antithrombin deficiency undergoing childbirth or surgery.
  Principal Investigator: Heghine Khachatryan
• ANB-002: Safety and Pharmacodynamics Study
  Single-dose evaluation in patients with Hemophilia B.
  Principal Investigator: Heghine Khachatryan
• TiUMBio TU7710 Phase Ib Clinical Trial
  Safety, pharmacokinetics, and pharmacodynamics study in patients with Hemophilia A or B.
  Principal Investigator: Heghine Khachatryan
• Role of Helicobacter pylori in Non-Hodgkin Lymphoma
  Exploring the bacterium’s role in the pathogenesis, diagnosis, treatment efficacy, and disease progression.
  Principal Investigator: Lusine Sahakyan
• ERNEST 3 – Observational Study of Myelofibrosis
  A modern clinical-epidemiological study under the European Leukemia Network (ELN).
  Principal Investigator: Maria Badikyan

Scientific Events and Conferences

In addition to conducting research, the Center organizes scientific conferences supported through various research grants, contributing to knowledge exchange and professional development.

Scientific Leadership and Research Staff

• Deputy Director for Scientific Division: Astghik Voskanyan
• Scientific Director: Heghine Khachatryan

Senior Researchers:

• Lusine Sahakyan
• Samvel Bardakhchyan
• Diana Soghomonyan

Researchers:

• Nerses Ghahramanyan
• Anna Sevoyan
• Anna Avagyan
• Lilit Matinyan
• Maria Badikyan
• Gevorg Avagyan
• Nare Martirosyan
• Gevorg Saghumyan
• Lusine Harutyunyan
• Karin Bediryan
• Gohar Tadevosyan

• Armine Sahakyan – Senior Laboratory Technician
• Naira Simonyan – Laboratory Technician