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Essential Thrombocythemia (ET) is a rare blood malignancy characterized by an abnormally elevated platelet count. Platelets play a crucial role in blood clotting, but their excess can lead to the formation of clots within blood vessels, thereby increasing the risk of heart attack or stroke.
In many cases, ET does not cause noticeable symptoms and is often detected incidentally during a routine blood test. When present, symptoms may include headaches, dizziness, burning or pain sensations in the hands and feet, and visual disturbances. Occasionally, bleeding complications may also occur.
Statistics: ET is rare, but it can be diagnosed at any age. However, it is more common in individuals over the age of 50, particularly in women.
Heredity: Essential Thrombocythemia, like other myeloproliferative neoplasms, is generally not inherited. The disease is associated with acquired mutations in the JAK2, CALR, or MPL genes.
